Home Blood cancer information Leukaemia Hairy cell leukaemia Hairy cell leukaemia treatment Side effects of hairy cell leukaemia treatment. As a general rule, while you are having treatment you will need to contact your doctor or hospital immediately if you have any of the following:. Chemotherapy kills cells that multiply quickly, such as leukaemic cells.
The DNA genetic material of a developing stem cell in the bone marrow is damaged. As a result, the number of healthy blood cells red cells, white cells and platelets is usually lower than normal. Doctors don't know why some cells become hairy cells and others don't.
Hairy cell leukemia is an uncommon hematological malignancy characterized by an accumulation of abnormal B lymphocytes. Hairy cell leukemia was originally described as histiocytic leukemia, malignant reticulosis, or lymphoid myelofibrosis in publications dating back to the s. The disease was formally named leukemic reticuloendotheliosis and its characterization significantly advanced by Bertha Bouroncle and colleagues at The Ohio State University College of Medicine in Its common name, which was coined in is derived from the "hairy" appearance of the malignant B cells under a microscope.
Hairy cell leukemia HCL is a rare type of blood and bone marrow cancer that affects your B lymphocytes, which are white blood cells that make antibodies to fight infections. These abnormal cells can take up the space of healthy B lymphocytes, which can weaken your immune system and make you susceptible to infections. HCL gets its name because the abnormal white blood cells look hairy under a microscope.
Hairy cell leukemia HCL is a neoplasm of mature B lymphoid cells. It affects predominately middle-aged to elderly adults, with a median age of 50 years. It has been diagnosed in younger patients, but is exceptionally uncommon in children.
We describe an unusual case of hairy cell leukemia HCL in a year-old male presenting with isolated skeletal disease as the initial manifestation without abnormal peripheral blood counts, bone marrow involvement, or splenomegaly. To the best of our knowledge, there have been only two previous reports of a similar case. The patient presented with pain in the right femur.
Hairy cell leukemia HCL is an uncommon chronic B-cell lymphoid malignancy. HCL is differentiated from other B-cell lymphoproliferative disorders by specific cytomorphological, immunophenotypic, and molecular features. InBouroncle et al. Due to its unique pathologic features, HCL has always drawn much attention from medical students, pathologists, and clinicians despite its low frequency of occurrence and excellent response to therapy.
Hairy cell leukemia HCL is a unique chronic lymphoproliferative disorder that can mimic or coexist with other clonal hematologic disorders and has been associated with autoimmune disorders. It should be entertained as an alternative diagnosis in patients with cytopenias being assigned the diagnosis of aplastic anemia, hypoplastic myelodysplastic syndrome, atypical chronic lymphocytic leukemia, B-prolymphocytic leukemia, or idiopathic myelofibrosis. Causative etiology or molecular defects remain unclear, although nonspecific chromosomal and molecular changes have been described.
Hairy cell leukemia is a rare, slow-growing cancer of the blood in which your bone marrow makes too many B cells lymphocytesa type of white blood cell that fights infection. These excess B cells are abnormal and look "hairy" under a microscope. As the number of leukemia cells increases, fewer healthy white blood cells, red blood cells and platelets are produced.