Yb1 breast colorectal cancer

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Woolley, Lance D. Shelling, Cristin G. Print, Antony W.

Objective: In published studies, Y-box binding protein-1 YB-1 correlated with the prognosis of patients with breast cancer BCbut the specific role of YB-1 is still unclear. Our study aimed to evaluate the prognostic value of YB-1 in BC patients using meta-analysis based on the published studies. Methods: We searched the relevant literatures deadline for June in databases, including PubMed, Embase, Medline and Cochrane library, and finally 8 studies were included in our study.

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YB-1 is a multifunctional protein that affects transcription, splicing, and translation. Overexpression of YB-1 in breast cancers causes cisplatin resistance. Recent data have shown that YB-1 is also overexpress in colorectal cancer.

Background: Y-Box—Binding YB1 protein represents a multifunctional protein, which plays a significant role in processes of proliferation, apoptosis and control of tumour cell response to toxic agents, including chemotherapy. The present study aimed at evaluating the prognostic significance of YB1 expression in breast cancer. Materials and Methods: We analyzed nuclear and cytoplasmic expression of YB1 in patients with stage II breast cancer, with 17 years of follow-up.

Colorectal cancer CRC is one of the most common and fatal malignancies worldwide. Novel prognostic biomarkers are urgently warranted to help improve the treatment of CRC. Y-box-binding protein 1 YB-1 has been identified as a multifunctional oncoprotein in various malignancies.

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The Y-box binding protein YB-1 is known to be a multifunctional transcription and translation factor during expression of several proteins. It is a vital oncoprotein that regulates cancer cell progression and proliferation. YB-1 is over-expressed in various human cancers such as breast cancer, colon cancer, lung cancer, gastric canceroesophageal cancer and glioblastoma.

We aimed to evaluate the relationships between nuclear YB-1 expression, epidermal growth factor receptor EGFR status, and poor clinical outcomes in patients with colorectal cancer CRC. Materials and Methods: Nuclear YB-1 expression was immunohistochemically analyzed in CRC tissues obtained from patients who underwent curative resection between and Correlations between nuclear YB-1 expression, various clinicopathological characteristics, EGFR status, and prognostic factors were evaluated.

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Mouse over the terms for more detail; many indicate links which you can click for dedicated pages about the topic. Data table showing topics related to specific cancers and associated disorders. Scope includes mutations and abnormal protein expression.

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.

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